Investments in the 45 most attractive healthcare stocks worldwide, regionally diversified and across sub sectors
Profiting from pent-up demand in Emerging Markets as well as from innovation in industrialized countries
Strong focus on quality mid caps and underweight in pharma stocks
Indexed performance (as at: 05.09.2025)
NAV: USD 229.73 (03.09.2025)
Rolling performance (05.09.2025)
I2-USD | Benchmark | |
03.09.2024 - 03.09.2025 | -4.98% | -11.11% |
03.09.2023 - 03.09.2024 | 11.66% | 19.71% |
03.09.2022 - 03.09.2023 | 4.42% | 9.70% |
02.09.2021 - 02.09.2022 | -21.02% | -12.10% |
Annualized performance (05.09.2025)
I2-USD | Benchmark | |
1 year | -4.98% | -11.11% |
3 years | 3.47% | 5.52% |
5 years | 1.36% | 5.53% |
Since Inception p.a. | 7.48% | 8.17% |
Cumulative performance (05.09.2025)
I2-USD | Benchmark | |
1M | 4.44% | 4.86% |
YTD | 6.71% | 2.93% |
1 year | -4.98% | -11.11% |
3 years | 10.79% | 17.51% |
5 years | 6.97% | 30.88% |
Since Inception | 83.78% | 93.92% |
Annual performance
I2-USD | Benchmark | |
2024 | -0.67% | 1.13% |
2023 | -2.72% | 3.76% |
2022 | -10.96% | -5.41% |
2021 | 6.23% | 19.80% |
Facts & Key figures
Investment Focus
The fund’s aim is to achieve capital growth in the long term, is actively managed and invests in global healthcare companies with innovative business models. Its investment universe consists of biotechnology and pharma companies, Show moreShow less
Investment suitability & Risk
Low risk
High risk
General Information
Investment Manager | Bellevue Asset Management AG |
Custodian | CACEIS BANK, LUXEMBOURG BRANCH |
Fund Administrator | CACEIS BANK, LUXEMBOURG BRANCH |
Auditor | PriceWaterhouseCoopers |
Launch date | 31.10.2016 |
Year end closing | 30. Jun |
NAV Calculation | Daily "Forward Pricing" |
Cut of time | 15:00 CET |
Management Fee | 0.70% |
Subscription Fee (max.) | 5.00% |
ISIN number | LU1587979177 |
Valor number | 36225694 |
Bloomberg | BVBAI2U LX |
WKN | A2DPAP |
Legal Information
Legal form | Luxembourg UCITS V SICAV |
SFDR category | Article 8 |
Redemption period | Daily |
Key data (31.08.2025, base currency USD)
Beta | 0.77 |
Volatility | 12.12 |
Tracking error | 8.13 |
Active share | 60.14 |
Correlation | 0.78 |
Sharpe ratio | -0.19 |
Information ratio | -0.39 |
Jensen's alpha | -3.10 |
No. of positions | 45 |
Portfolio
Top 10 positions
Market capitalization
Geographic breakdown
Breakdown by sector
Benefits & Risks
Benefits
- Investments in the 45 most attractive healthcare stocks worldwide.
- Proprietary investment process: Half-yearly company evaluation and rebalancing.
- Underweighting of pharma and US stocks against the relevant healthcare indices.
- Strong focus on quality mid-caps.
- Bellevue – healthcare pioneer since 1993 and today one of the biggest independent investors in the sector in Europe.
Risks
- The fund actively invests in equities. Equities are subject to strong price fluctuations and so are also exposed to the risk of price losses.
- The fund may invest a proportion of its assets in financial instruments that might under certain circumstances have a relatively low level of liquidity, which can in turn affect the fund’s liquidity.
- The fund invests in foreign currencies, which means a corresponding degree of currency risk against the reference currency.
- Investing in Emerging Markets entails the additional risk of political and social instability.
- The fund may engage in derivatives transactions. The increased opportunities gained come with an increased risk of losses.
Review / Outlook
Global equities recovered in August 2025, with the MSCI World Index rising 2.6%. Healthcare outperformed broader equities, with the MSCI World Health Care Index up 5.1% on the back of improved operating certainty and rebounds in several megacaps, bringing the sector back into positive territory ytd at 2.8%. The Bellevue Healthcare Strategy (LUX) Fund (I shares) gained 3.1% in US dollars, underperforming its benchmark for the month by 208 bps. This was driven by its higher exposure to Asian healthcare, which underperformed in August but has been strong ytd.
Policy developments provided support to sector performance for the first time in many months, as the US and EU clarified that tariffs on imported EU-manufactured drugs will begin at zero and be capped at 15% regardless of any 232 investigation outcomes. At the Jackson Hole Symposium, Fed Chair Powell signaled support for September rate cuts, which lifted sentiment in biotechnology.
Sector heavyweight UnitedHealth rebounded 24% after Berkshire Hathaway disclosed a USD 1.6 bn stake (not invested, but the news supported healthcare services valuations within the fund). Beyond healthcare services, Teva Pharmaceuticals gained 19% on the back of strong Q2 results and supportive generic tariff commentary, Novo Nordisk rose 18% due to mixed competitor data in obesity, AbbVie climbed 11% after posting strong Q2 results, and Galderma advanced 11% following the successful launch of Nemluvio.
President Trump’s July 31 letters highlighted frustration with the lack of progress on his most-favored nation (MFN) Executive Order, pressing for Medicaid pricing alignment, MFN guarantees on new drugs, revenue returns to US taxpayers, and direct MFN pricing from biopharma. While the focus on Medicaid rather than Medicare points to a possible compromise, significant uncertainty remains. The importance of Section 232 drug investigations has diminished following the US-EU tariff agreement capping drug tariffs at 15%, in our view. A potential policy outcome could involve industry guarantees of essential medicine supplies, limited MFN adoption, and US CapEx commitments – measures that can be presented politically as victories but would have relatively modest earnings implications for the sector.
Healthcare equities remain derated, now accounting for less than 9% of the S&P 500 despite representing around 18% of US GDP. Greater clarity on drug pricing policy could attract value investors back, while weakening US economic indicators may also restore interest in the sector as a defensive hedge. Structurally, long-term drivers such as aging populations, growing healthcare access in emerging markets, and innovation in areas like robotics and AI continue to provide support. Innovation remains key to addressing rising societal healthcare costs by improving efficiency and reducing the burden of long-term care. Against this backdrop, the fund maintains a selective, high-conviction approach with diversified exposure across global healthcare.
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Senior Sales Germany
Alexander Jostes