BB Adamant Biotech (Lux)

Biotech sector with sustainable, strong sales and earnings growth thanks to high innovation level 

 Expiring patents of pharma companies lead to high M&A activity (patent cliff)

 Valuations very attractive on historical average over the last 10 years

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Please find a more detailed description of share classes here.

Investment Focus

ISIN-No. LU0415392322

The Fund invests worldwide in companies active in the biotechnology sector. Experienced sector specialists focus on profitable mid- and large-cap companies with an established product portfolio. Stock selection is based on fundamental analysis. The selection of portfolio companies is entirely bottom-up, independent of benchmark weightings.

Indexed performance (as at: 24.09.2021)

NAV: USD 675.31 (23.09.2021)


Fonds (Brutto)
01 Jan 2010 - 01 Jan 2010
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Rolling performance (23.09.2021)

B-USDBenchmark
23.09.2020 - 23.09.202126.19%30.01%
23.09.2019 - 23.09.202024.23%26.37%
23.09.2018 - 23.09.2019-11.51%-11.99%
23.09.2017 - 23.09.20183.38%7.67%

Annualized performance (23.09.2021)

B-USDBenchmark
1 year26.19%30.01%
3 years11.50%13.04%
5 years9.74%11.58%
Since Inception p.a.14.46%18.00%

Cumulative performance (23.09.2021)

B-USDBenchmark
1M-0.74%1.08%
YTD11.34%13.36%
1 year26.19%30.01%
3 years38.73%44.59%
5 years59.22%72.99%
Since Inception440.25%690.08%

Annual performance

B-USDBenchmark
202023.01%25.69%
201927.86%24.41%
2018-15.17%-9.32%
201723.13%21.06%

Investment Focus

The Fund invests worldwide in companies active in the biotechnology sector. Experienced sector specialists focus on profitable mid- and large-cap companies with an established product portfolio. Stock selection is based on fundamental analysis, in particular of the medical indications addressed, the means of efficacy and the market potential. A global network of experts spanning scientific and industrial fields supports the Management Team in forming opinions and making investment decisions. The selection of portfolio companies is entirely bottom-up, independent of benchmark weightings.Show moreShow less

Investment suitability & Risk

Low risk

High risk

The Fund’s investment objective is to generate attractive and competitive capital growth in the long term. It is therefore particularly suited to investors with an investment horizon of at least 5 years who want to selectively diversify their portfolio with investments in the biotechnology sector and who are willing to accept the equity risks typical of this sector.

General Information

Investment ManagerBellevue Asset Management AG
CustodianRBC Investor Services, Luxembourg
Fund AdministratorRBC Investor Services, Luxembourg
AuditorPriceWaterhouseCoopers
Launch date02.04.2009
Year end closing30. Jun
NAV CalculationDaily "Forward Pricing"
Cut of time15:00 CET
Management Fee1.60%
Subscription Fee (max.)5.00%
ISIN numberLU0415392322
Valor number3882743
BloombergBBBIOUB LX
WKNA0RPSP
Total expense ratio (TER)2.26% (31.08.2021)

Legal Information

Legal formSICAV Luxembourg jurisdiction
SFDR categoryArticle 8

Key data (31.08.2021, base currency USD)

Beta0.89
Volatility25.70
Tracking error9.27
Active share44.10
Correlation0.94
Share ratio0.50
Information ratio-0.23
Jensen's alpha-0.85
No. of positions55

Top 10 positions

Moderna
Gilead Sciences
Regeneron Pharma.
Genmab
Vertex Pharmaceut.
Seagen
Biogen Idec
Illumina
Amgen
Horizon Pharma
8.1%
5.8%
5.5%
3.8%
3.7%
3.4%
3.4%
3.3%
3.2%
2.6%

Market capitalization

0 - 1 bn
1 - 2 bn
2 - 5 bn
5 - 15 bn
15 - 20 bn
> 20 bn
Others
2.8%
3.4%
9.8%
16.5%
8.6%
56.3%
2.6%

Geographic breakdown

United States
Denmark
Germany
China
Switzerland
Belgium
Great Britain
Japan
Others
Cash
77.0%
7.8%
3.5%
2.3%
2.0%
1.6%
1.6%
1.2%
0.9%
2.4%

Breakdown by sector

Oncology
Infectious Diseases
Orphan Drugs
Neurolog. Disorders
Specialty Pharma
Pulmonary Diseases
Life Science Supply
Infectious Disease
Central Nervous Syst.
Autoimmune disease
Metabolic Diseases
Others
Cash
30.2%
16.1%
8.0%
6.8%
3.9%
3.7%
3.3%
3.1%
3.0%
2.6%
2.2%
14.7%
2.4%

Currency

USD
DKK
EUR
CHF
JPY
HKD
Others
84.4%
7.8%
2.8%
1.5%
1.2%
1.1%
1.4%

Opportunities

  • New innovative drugs are powering sustainable momentum in the biotech sector.
  • Attractively valued large-cap biotechs.
  • Expiring pharmaceutical patents trigger a rise in M&A activity.
  • Focus on US biotech companies with strong growth potential.
  • Bellevue has been a Healthcare pioneer since 1993 and is one of the biggest independent investors in the sector in Europe today.

Risks

  • Equities are subject to strong price fluctuations and so are also exposed to the risk of price losses.
  • Market, industry or company factors can lead to strong short-term price fluctuations
  • The fund invests in foreign currencies, which means a corresponding degree of currency risk against the reference currency.
  • Investing in emerging markets entails the additional risk of political and social instability.
  • The fund may invest in financial instruments that might have a rather low level of liquidity, which can in turn affect the fund’s liquidity.

Global stock markets marched higher in August. The S&P Index closed the month with a gain of 3.0%, the Nasdaq Biotech Index +4.2% and the BB Adamant Biotech (Lux) Fund +2.0% (USD / B shares).

The re-opening of the global economy continued in August. Many industrialized countries have eased their pandemic restrictions and this was reflected in the good economic data published in August. However, the rapid spread of the delta variant, which has caused new cases to climb, especially among unvaccinated people, is a cause for concern. Data from the UK and Israel suggest that vaccine effectiveness declines about six to eight months after vaccination. For this reason, some countries have begun to administer a booster dose to particularly vulnerable people. The US central bank said it could start to dial back its expansionary monetary policy sometime this year, but any such action would depend on a further improvement in employment data and the repercussions of the delta variant.

The following companies made the best contribution to the portfolio's performance in August: Early in the month Regeneron reported strong quarterly results, driven by the sales of its REGEN-CoV antibody cocktail for COVID-19 patients. The New York-based biotech company also benefited from good news about Dupixent and Eylea, two drugs that were developed in collaboration with business partners. Seagen added a second bladder cancer program to its pipeline by acquiring rights to a HER2 antibody drug conjugate (ADC) from RemeGen. Alnylam, a specialist in RNAi therapeutics, was marked up after publishing strong sales for its approved products Onpattro, Givlaari and Oxlumo, and it increased its sales guidance for the current fiscal year.

Immuno-oncology firm Beigene was a performance detractor. Its shares retreated in the wake of political action in China and the repercussions that had on the country's stock market. This political action also pressured the shares of two other companies in the portfolio, Innovent and Zai Labs. Jazz Pharmaceuticals plunged after releasing its quarterly results, which raised fears of generic competition gaining entry into the narcolepsy market. Fate Therapeutics presented good data for its B-cell lymphoma program, but could not beat investors’ high expectations.

Our stance towards the biotech sector remains positive in view of its strong fundamentals and very attractive valuations (average 2022 P/E of 14x and PEG of 1.1 for large caps). These are still very attractive multiples compared to the biotech sector's historical valuations and the current ratios for the pharma sector (P/E 16x, PEG 2.4) and the S&P Index (P/E 21x, PEG 2.1).

The companies in our portfolio are working on technologies or products for novel treatment solutions. We are also invested in selected specialty pharma companies that offer high growth rates and moderate valuations. The BB Adamant Biotech (Lux) Fund is well-positioned to profit from the milestones that are expected to be reached in 2021 and 2022. The regulatory environment favors the innovation coming out of biotech labs and the coronavirus crisis has improved the image of drug developers. Large pharma companies have acquired a number of companies in the fund's portfolio – Loxo, Array, Medicines Company, Myokardia and Alexion – and we expect more M&A deals to be announced during the coming months.

Past performance is not a reliable indicator of future results and can be misleading. As the sub-fund is denominated in a currency that may differ than an investor’s base currency, changes in the rate of exchange may have an adverse effect on prices and incomes. Performance is shown net of fees and expenses for the relevant share class over the reference period. All performance figures reflect the reinvestment of dividends and do not take into account the commissions and costs incurred on the issue and redemption of shares, if any. Individual costs are not taken into account and would have a negative impact on the performance. With an investment amount of EUR 1,000 over an investment period of five years, the investment result in the first year would be reduced by the front-end load of up to EUR 50 (5%) as well as by additional individual custody charges. In subsequent years, the investment result would also be reduced by the individual custody account costs incurred. The reference benchmark of this class is used for performance comparison purposes only (dividend reinvested). No benchmark is directly identical to a sub-fund, thus the performance of a benchmark is not a reliable indicator of future performance of the sub-fund it is compared to. There can be no assurance that a return will be achieved or that a substantial loss of capital will not be incurred. All figures in base currency in %, calculated by the total return / BVI method.Show moreShow less

  • Lead Portfolio Manager

    Christian Lach

    After working as a member of the Management Team BB Biotech/ BB Medtech at Bellevue Asset Management AG until 2008, Christian Lach was Senior Portfolio Manager Biotechnology at Adamant Biomedical Investments AG. Since 2015, he has been working again at Bellevue Asset Management as Senior Portfolio Manager Healthcare Funds & Mandates. He holds a degree in natural sciences (Dipl. Natw. ETH) and a doctorate in economics from the University of St. Gallen (Dr. oec HSG).
  • Portfolio Manager

    Samuel Stursberg

    After receiving his Master of Science in Biochemistry from the University of Basel and a degree in Economics from the University of St. Gallen (lic. oec. HSG), Samuel Stursberg conducted stock analysis at Bank Sarasin among others and was Head Research at Adamant Biomedical Investments AG before joining Bellevue Asset Management as Head Research health Care Funds & Mandates in 2015.
  • Analyst

    Lukas Leu

    Lukas Leu has been a Healthcare Analyst at Bellevue Asset Management since 2021. He holds a PhD in biochemistry from the Swiss Federal Institute of Technology in Zurich. He previously worked as a research assistant at his alma mater and as an equity research analyst in the healthcare sector at Julius Baer.
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